ROTNA KHATUN1*and ARJU MIAH2
1Scientific Officer, Department of Cytogenetics, Genetic Resources and Seed Division, Bangladesh Jute Research Institute, Manik Mia Avenue, Dhaka-1207, 2Principal Scientific Officer, Department of Cytogenetics, Genetic Resources and Seed Division, Bangladesh Jute Research Institute, Manik Mia Avenue, Dhaka-1207, Bangladesh, Email: arjuminal46@gmail.com. *Corresponding author’s E-mail: rkrotna1050@gmail.com
ABSTRACT
The study was conducted at the Department of Cytogenetics, Genetic Resources and Seed Division, BJRI. Wetting refers to the ability of a liquid to spread over a solid surface while maintaining contact with it. This process involves the liquid and gas moving across the surface of particles, resulting in the disappearance of the solid-vapor interface and the formation of a solid-liquid interface. These properties have found widespread application in the field of biomolecular condensates. Biomolecular condensates are membrane less organelles formed through the liquid-liquid phase separation of biological macromolecules within cells, serving diverse purposes. Recently, the wetting phenomenon in biomolecular condensates has emerged as a significant regulator of various cellular events. This review aims to comprehensively understand the physical, chemical, and biological principles, properties, and functional significance of wetting in biomolecular condensates. Specifically, it explores wetting in biomolecular condensates such as Loewy bodies, stress granules, P-bodies, nucleoli, Cajal bodies and colloid nodules of the thyroid gland, as well as serum albumin and globulins. Additionally, the role of wetting in cytoskeletal condensate filaments, bimolecular cytoplasmic condensates, plasma membrane-associated condensate bindings, and determining end-points in wet granulation properties for biomolecule concentration will be described.
Keywords: Wetting, Liquid-liquid phase separation, Biomolecular condensates, Membrane less organelles and Colloidal emulsions.
* Review paper